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Reconstitution of DNA strand exchange mediated by Rhp51 recombinase and two mediators.
Kurokawa Y, Murayama Y, Haruta-Takahashi N, Urabe I and Iwasaki H.
PLoS Biol. (2008) 6:e88.
Molecular characterization of the Schizosaccharomyces pombe nip1+/ctp1+ gene in DNA double strand break repair in association with the Mre11-Rad50-Nbs1 complex.
Akamatsu Y, Murayama Y, Yamada T, Nakazaki T, Tsutsui Y, Ohta K and Iwasaki H.
Mol. Cell. Biol. (2008) 28:3639-3651.
Mus81 is essential for sister chromatid recombination at broken replication forks.
Roseaulin L, Yamada Y, Tsutsui Y, Russell P, Iwasaki H and Arcangioli B.
EMBO J. (2008) 27:1378-1387.
Formation and branch migration of Holliday junctions mediated by eukaryotic recombinases.
Murayama Y, Kurokawa Y, Mayanagi K and Iwasaki H.
Nature (2008) 451:1018-1021.
Fission yeast Swi5 protein, a novel DNA recombination mediator*.
Haruta N, Akamatsu Y, Tsutsui Y, Kurokawa Y, Murayama Y, Arcangioli B and Iwasaki H.
DNA Repair (Amst) (2008) 7: 1-9. (*invited review)
Fission yeast Swi5/Sfr1 and Rhp55/Rhp57 differentially regulate Rhp51-dependent recombination outcomes.
Akamatsu Y, Tsutsui Y, Morishita T, Siddique MS, Kurokawa Y, Ikeguchi M, Yamao F, Arcangioli B, Iwasaki H.
EMBO J. (2007) 26:1352-1362.
The Swi5-Sfr1 complex stimulates Rad51- and Dmc1-mediated DNA strand exchange in vitro.
Haruta N, Kurokawa Y, Murayama Y, Akamatsu Y, Unzai S, Tsutsui Y and Iwasaki H.
Nat. Struct. Mol. Biol. (2006) 13:823-730.
Role of the Schizosaccharomyces pombe F-box DNA helicase in processing recombination intermediates.
Morishita T, Furukawa F, Sakaguchi C, Toda T, Carr AM, Iwasaki H and Shinagawa H.
Mol. Cell. Biol. (2005) 25:8074-8083.
Genetic and physical interactions between Schizosaccharomyces pombe Mcl1 and Rad2, Dna2 and DNA polymerase alpha: evidence for a multifunctional role of Mcl1 in DNA replication and repair.
Tsutsui Y, Morishita T, Natsume T, Yamashita K, Iwasaki H, Yamao F, Shinagawa H.
Curr Genet. (2005) 48:34-43
Functional overlap between RecA and MgsA (RarA) in the rescue of stalled replication forks in Escherichia coli.
Shibata T, Hishida T, Kubota Y, Han YW, Iwasaki H, and Shinagawa H.
Genes Cells. (2005) 10:181-191.
Rad62 protein functionally and physically associates with the Smc5/Smc6 protein complex and is required for chromosome integrity and recombination repair in fission yeast.
Morikawa H, Morishita T, Kawane S, Iwasaki H, Carr AM, and Shinagawa H.
Mol. Cell. Biol. (2004) 24:9401-9413.
Two different Swi5-containing protein complexes are involved in mating-type
switching and recombination repair in fission yeast.
Akamatsu Y, Dziadkowiec D, Ikeguchi M, Shinagawa H, Iwasaki H.
Proc Natl Acad Sci USA. (2003) 100: 15770-15775.
Molecular Characterization of the Schizosaccharomyces pombe nbs1+ Gene Involved
in DNA Repair and Telomere Maintenance.
Ueno M, Nakazaki T, Akamatsu Y, Watanabe K, Tomita K, Lindsay HD, Shinagawa
H,
and Iwasaki H.
Mol. Cell. Biol. (2003) 23:6553-6563.
Competition between the Rad50 complex and the Ku heterodimer reveals a role
for Exo1 in processing double-strand breaks but not telomeres.
Tomita K, Matsuura A, Caspari T, Carr AM, Akamatsu Y, Iwasaki H, Mizuno K,
Ohta K, Uritani M, Ushimaru T, Yoshinaga K, and Ueno M.
Mol. Cell. Biol. (2003) 23:5186-5197.
The Schizosaccharomyces pombe rad60 gene is essential for repairing double-strand
DNA breaks spontaneously occurring during replication and induced by DNA-damaging
agents.
Morishita T, Tsutsui Y, Iwasaki H and Shinagawa H.
Mol. Cell. Biol. (2002) 22:3537-3548.
Multiple interactions among the components of the recombinational DNA repair
system in Schizosaccharomyces pombe.
Tsutsui Y, Khasanov FK, Shinagawa H. Iwasaki H and Bashkirov VI.
Genetics (2001) 159:91-105.
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Direct observation of DNA rotation during branch migration of Holliday junction DNA by Escherichia coli RuvA-RuvB protein complex.
Han YW, Tani T, Hayashi M, Hishida T, Iwasaki H, Shinagawa H, Harada Y.
Proc Natl Acad Sci USA. (2006) 103:11544-11548.
Structue-function analysis of the three domains of RuvB motor protein.
Ohnishi T, Hishida T, Harada Y, Iwasaki H, and Shinagawa H.
J. Biol. Chem. (2005) 280:30504-30510.
Role of the RuvAB protein in avoiding spontaneous formation of deletion mutations in the Escherichia coli K-12 endogenous tonB gene.
Mashimo K, Nagata Y, Kawata M, Iwasaki H, and Yamoto K.
Biochem Biophys Res Commun. (2004) 323:197-203.
Direct evidence that a conserved arginine in RuvB AAA+ ATPase acts as an
allosteric effector for the ATPase activity of the adjacent subunit in a
hexamer.
Hishida T, Han YW, Fujimoto S, Iwasaki H, Shinagawa H.
Proc Natl Acad Sci USA. (2004) 101:9573-9577.
Uncoupling of the ATPase activity from the branch migration activity of
RuvAB protein complexes containing both wild-type and ATPase-defective RuvB
proteins.
Hishida T, Iwasaki H, Han YW, Ohnishi T, and Shinagawa H.
Genes Cells. (2003) 8:721-730.
Crystal Structure of the RuvA-RuvB Complex: A Structural Basis for the Holliday
JunctionMigrating Motor Machinery.
Yamada K, Miyata T, Tsuchiya D, Oyama T, Fujiwara Y, Ohnishi T, Iwasaki
H,
Shinagawa H, Ariyoshi M, Mayanagi K, and Morikawa K.
Mol. Cell. (2002) 10:671-681.
Parallel symmetric immobile DNA junctions as substrates for E. coli RuvC
Holliday junction resolvase.
Sha R, Liu F, Iwasaki H and Seeman NC.
Biochemistry (2002) 41:10985-10993.
A unique β-hairpin protruding from AAA+, ATPase domain of RuvB motor protein
is involved in the interaction with RuvA DNA recognition protein for branch
migration of Holliday junctions.
Han YW, Iwasaki H, Miyata T, Mayanagi K, Yamada K, Morikawa K and Shinagawa
H.
J. Biol. Chem. (2001) 276:35024-35028.
Evidence that phenylalanine 69 in Escherichia coli RuvC resolvase forms
a stacking interaction during binding and destabilization of a Holliday junction
DNA substrate.
Yoshikawa M, Iwasaki H and Shinagawa H.
J. Biol. Chem. (2001) 276:10432-10436.
Crystal structure of the Holliday junction migration motor protein RuvB
from Thermus thermophilus HB8.
Yamada K, Kunishima N, Mayanagi K, Ohnishi .T, Nishino T, Iwasaki H, Shinagawa
H and Morikawa K.
Proc Natl Acad Sci USA. (2001) 8:1442-1447.
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A DNA polymerase a accessory protein, Mcl1, is required for propagation of centromere structures in fission yeast
NatsumeT, Tsutsui Y, Sutani T, Dunleavy EM,Pidoux AL, Iwasaki H, Shirahige K, Allshire RC, and Yamao F
PLoS One (2008) 3:e2221.
Role of the Escherichia coli RecQ DNA helicase in SOS signaling and genome stabilization at stalled replication forks.
Hishida T, Yong-Woon Han Y-W, Shibata T, Kubota Y, Ishino Y, Iwasaki H, and Shinagawa H.
Genes Dev. (2004) 18:1886-1897.
1-Methyl-4-phenylpyridinium ion, a toxin that can cause parkinsonism, alters
branched structures of DNA.
Iwaasa M, Umeda S, Ohsato T, Takamatsu C, Fukuoh A, Iwasaki H, Shinagawa
H, Hamasaki N and Kang D.
J. Neurochem. (2002) 82:30-37.
Saccharomyces cerevisiae MGS1 is essential in strains deficient in the RAD6-dependent
DNA damage tolerance pathway.
Hishida T, Ohno T, Iwasaki H and Shinagawa, H.
EMBO J. (2002) 21:2019-2029.
p53 blocks RuvAB promoted branch migration and modulates resolution of Holliday
junctions by RuvC.
Prabhu VP, Simons AM, Iwasaki H, Gai D, Simmons DT and Chen J.
J. Mol. Biol. (2002) 316:1023-1032.
A yeast gene, MGS1, encoding a DNA-dependent AAA(+) ATPase is required to
maintain genome stability.
Hishida T, Iwasaki H, Ohno T, Morishita T and Shinagawa H.
Proc Natl Acad Sci USA. (2001) 98:8283-8289.
Mutagenic and nonmutagenic bypass of DNA lesions by Drosophila DNA polymerases
Δpolη and Δpolι.
Ishikawa T, Uematsu N, Mizukoshi T, Iwai S, Iwasaki H, Masutani C, Hanaoka
F, Ueda R, Ohmori H and Todo T.
J. Biol. Chem. (2001) 276:15155-15163.
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１）相同組換えのメディーエーター
春田（高橋）奈美，岩崎博史. 生化学 （2007）79：449-453．
２）相同組換えと共役した複製フォークの再生研究の新展開
−崩壊した複製フォークの再生に関わる新規組換え修復因子−
筒井康博，岩崎博史. 実験医学 （2007）25:718-719
３）ホリデイ構造とDNA 組換え修復．
岩崎博史，品川日出夫．蛋白質核酸酵素（2001）46：995-1003
４）RucABC リゾルバゾームによるHolliday 構造のプロセッシング
−立体構造からみた相同組換えの後期過程−
有吉真理子，山田和弘，岩崎博史．蛋白質核酸酵素（2001）46：1625-1634
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